Description

4H-1,3-Dioxolo4,5-Cpyrrole, 4-(1,1-Dimethylethyl)Dimethylsilyloxymethyltetrahydro-2,2-Dimethyl-6-(3-Pyridinyl)-, (3Ar,4R,6S,6As)- is a high-purity, complex heterocyclic building block featuring a fused dioxolopyrrole core with a silyl-protected hydroxymethyl group and a pyridinyl substituent. This compound is of significant value as a key chiral intermediate in advanced pharmaceutical synthesis, particularly for the development of novel therapeutic agents. It is primarily sought after by pharmaceutical R&D departments and fine chemical manufacturers engaged in the production of complex, biologically active molecules.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of proprietary drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Process Chemistry Development: Used in route scouting and optimization for the scalable production of active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a versatile building block for constructing compound libraries aimed at high-throughput screening and structure-activity relationship (SAR) studies.
• Asymmetric Synthesis: Leverages its defined stereochemistry (3aR,4R,6S,6aS) for the stereoselective construction of complex molecular architectures.
• Nucleoside/Nucleotide Analogue Research: The protected dioxolopyrrole structure makes it relevant for research into modified nucleosides with potential antiviral or anticancer activity.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for cGMP production of clinical trial materials and commercial APIs.

Basic Information

Product Name	4H-1,3-Dioxolo4,5-Cpyrrole, 4-(1,1-Dimethylethyl)Dimethylsilyloxymethyltetrahydro-2,2-Dimethyl-6-(3-Pyridinyl)-, (3Ar,4R,6S,6As)-
CAS No.	188744-87-8
Molecular Formula	C20H33NO4Si
Molecular Weight	379.57 g/mol
Synonyms	(3aR,4R,6S,6aS)-4-[[(tert-Butyldimethylsilyl)oxy]methyl]-2,2-dimethyl-6-(3-pyridinyl)tetrahydro-4H-[1,3]dioxolo[4,5-c]pyrrole; 4-((tert-Butyldimethylsilyloxy)methyl)-2,2-dimethyl-6-(pyridin-3-yl)tetrahydro-4H-[1,3]dioxolo[4,5-c]pyrrole; TBDMS-protected dioxolopyrrole pyridine derivative; Chiral dioxolopyrrole intermediate; tert-Butyldimethylsilyl (3aR,4R,6S,6aS)-2,2-dimethyl-6-(3-pyridinyl)tetrahydro-4H-[1,3]dioxolo[4,5-c]pyrrol-4-ylmethyl ether
EINECS	Contact for details

Quality Control

This high-value intermediate is produced under strict quality control protocols to ensure batch-to-batch consistency and purity essential for pharmaceutical applications. Our quality system is designed to meet the exacting standards of cGMP (current Good Manufacturing Practice) for advanced intermediates. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The compound is moisture-sensitive (hygroscopic); containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.