Description

4H-1,3-Dioxolo4,5-Cpyrrole, 4-(4-Chlorophenyl)-6-(1,1-Dimethylethyl)Dimethylsilyloxymethyltetrahydro-2,2-Dimethyl-, (3As,4S,6R,6Ar)- is a high-purity, complex heterocyclic organic compound with a defined stereochemistry, identified by CAS No. 188744-81-2. This compound serves as a critical advanced intermediate in the synthesis of novel active pharmaceutical ingredients (APIs) and fine chemicals, where its specific stereocenters are essential for biological activity. It is primarily required by pharmaceutical R&D laboratories and custom synthesis facilities focused on developing new therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key chiral building block in the multi-step synthesis of novel, potent drug candidates.
• Organic Synthesis Research: Used in academic and industrial research to explore new chemical entities and reaction pathways involving complex fused-ring systems.
• Agrochemical Development: Potential intermediate for creating new generation pesticides and herbicides with specific stereochemical requirements.
• Material Science Precursor: Can be utilized in the development of specialty polymers or organic electronic materials due to its unique molecular architecture.
• Process Chemistry Scale-up: Serves as a defined intermediate for process optimization and kilogram-scale production in contract manufacturing organizations (CMOs).

Basic Information

Product Name	4H-1,3-Dioxolo4,5-Cpyrrole, 4-(4-Chlorophenyl)-6-(1,1-Dimethylethyl)Dimethylsilyloxymethyltetrahydro-2,2-Dimethyl-, (3As,4S,6R,6Ar)-
CAS No.	188744-81-2
Molecular Formula	C22H34ClNO3Si
Molecular Weight	424.05 g/mol
Synonyms	(3aS,4S,6R,6aR)-4-(4-Chlorophenyl)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxymethyl]tetrahydro-2,2-dimethyl-4H-[1,3]dioxolo[4,5-c]pyrrole; 4H-1,3-Dioxolo[4,5-c]pyrrole, 4-(4-chlorophenyl)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxymethyl]tetrahydro-2,2-dimethyl-, (3aS,4S,6R,6aR)-; tert-Butyldimethyl((((3aS,4S,6R,6aR)-4-(4-chlorophenyl)-2,2-dimethyltetrahydro-4H-[1,3]dioxolo[4,5-c]pyrrol-6-yl)methoxy)silane; (3aS,4S,6R,6aR)-6-((tert-Butyldimethylsilyloxy)methyl)-4-(4-chlorophenyl)-2,2-dimethyltetrahydro-4H-[1,3]dioxolo[4,5-c]pyrrole; TBDMS-protected pyrrolidine-dioxolane intermediate.
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality management systems to ensure identity, purity, and stereochemical integrity. Our standard pharmaceutical-grade material is characterized using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing assay, enantiomeric excess, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is light-sensitive and should be stored away from direct light. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent potential degradation. Isolate from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.