Description

Ethyl 1-Boc-2-oxopyrrolidine-3-carboxylate is a high-purity, protected amino acid derivative widely used as a critical chiral building block in advanced organic synthesis. This compound is essential for the efficient construction of complex molecular architectures, particularly in pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists in the fine chemical and pharmaceutical industries for the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of proline-based drug molecules and peptidomimetics.
• API Development: Used in the research and process development of Active Pharmaceutical Ingredients (APIs), especially those containing pyrrolidine or proline scaffolds.
• Peptide Chemistry: Serves as a protected proline analog for the solid-phase and solution-phase synthesis of modified peptides.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to introduce stereogenic centers.
• Chemical Biology Probes: Utilized in the development of enzyme inhibitors and molecular probes for biological target validation.
• Custom Synthesis: A foundational block for contract research and manufacturing organizations (CROs/CMOs) producing custom fine chemicals for clients.

Basic Information

Product Name	Ethyl 1-Boc-2-oxopyrrolidine-3-carboxylate
CAS No.	188528-95-2
Molecular Formula	C₁₂H₁₉NO₅
Molecular Weight	257.28 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-3-(ethoxycarbonyl)-2-pyrrolidinone; 3-(Ethoxycarbonyl)-1-[(2-methyl-2-propanyl)oxycarbonyl]-2-pyrrolidinone; 1-Boc-3-(ethoxycarbonyl)-2-pyrrolidinone; Ethyl 1-(tert-butoxycarbonyl)-2-oxo-3-pyrrolidinecarboxylate; 2-Pyrrolidinone, 3-(ethoxycarbonyl)-1-[(2-methyl-2-propanyl)oxycarbonyl]-; 1-Boc-3-carbethoxy-2-pyrrolidinone; N-Boc-3-carbethoxy-2-pyrrolidinone; 3-Carbethoxy-1-Boc-2-pyrrolidinone
EINECS	Contact for details

Quality Control

Our Ethyl 1-Boc-2-oxopyrrolidine-3-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring traceability, consistency, and reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.