Description

(R)-Methyl 2-((tert-Butoxycarbonyl)Amino)-3-Hydroxy-2-Methylpropanoate CAS NO 188476-28-0 is a high-purity, non-natural amino acid derivative featuring a chiral center and a protected amine group. This compound is a critical chiral building block for the synthesis of complex molecules, offering precise stereochemical control. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), peptide mimetics, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel therapeutic agents and APIs.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce specific, protected amino acid motifs.
• Protease Inhibitor Development: Serves as a core structural component for designing enzyme inhibitors.
• Chemical Biology Research: Employed in the study of protein-protein interactions and as a molecular probe.
• Asymmetric Synthesis: Utilized as a starting material or auxiliary in catalytic asymmetric reactions to construct complex chiral architectures.
• Custom Synthesis & Contract Manufacturing: Supplied for bespoke chemical synthesis projects requiring high stereochemical purity.

Basic Information

Product Name	(R)-Methyl 2-((tert-Butoxycarbonyl)Amino)-3-Hydroxy-2-Methylpropanoate
CAS No.	188476-28-0
Molecular Formula	C10H19NO5
Molecular Weight	233.26 g/mol
Synonyms	(R)-Methyl 2-(Boc-amino)-3-hydroxy-2-methylpropanoate; (R)-2-((tert-Butoxycarbonyl)amino)-3-hydroxy-2-methylpropanoic acid methyl ester; Boc-D-Threonine(OMe); Methyl (R)-2-[(tert-butoxycarbonyl)amino]-3-hydroxy-2-methylpropanoate; (R)-Methyl 2-(tert-butoxycarbonylamino)-3-hydroxy-2-methylpropionate; Boc-D-β-Methylserine methyl ester; (2R)-2-[(tert-Butoxycarbonyl)amino]-3-hydroxy-2-methylpropanoic acid methyl ester
EINECS	Contact for details

Quality Control

Our (R)-Methyl 2-((tert-Butoxycarbonyl)Amino)-3-Hydroxy-2-Methylpropanoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for advanced synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability and consistent batch-to-batch performance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere if specified and kept in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.