Description

2-Pyridinecarboxylicacid,1,2,3,6-Tetrahydro-6-Oxo-,Methylester,(R)-(9Ci) is a high-purity, chiral piperidine derivative that serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in organic synthesis. Its value lies in its stereochemically defined (R)-configuration, which is essential for imparting specific biological activity in final drug molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in the areas of central nervous system (CNS) agents and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Used as a building block for constructing enantiomerically pure compounds in medicinal chemistry research.
• Neurological Research: Employed in the development and study of potential drug candidates targeting neurological pathways and receptors.
• Chemical Biology: Acts as a precursor or a probe in the study of enzyme mechanisms and biological interactions.
• Process Chemistry: Serves as a starting material for scaling up the production of specialty fine chemicals under GMP conditions.

Basic Information

Product Name	2-Pyridinecarboxylicacid,1,2,3,6-Tetrahydro-6-Oxo-,Methylester,(R)-(9Ci)
CAS No.	188194-94-7
Molecular Formula	C8H11NO3
Molecular Weight	169.18 g/mol
Synonyms	(R)-1,2,3,6-Tetrahydro-6-oxonicotinic acid methyl ester; Methyl (R)-1,2,3,6-tetrahydro-6-oxopyridine-2-carboxylate; (R)-Methyl 6-oxo-1,6-dihydropyridine-2-carboxylate; (R)-Methyl 2,3-dihydro-6-oxo-1H-pyridine-2-carboxylate; (R)-Methyl 1,2,3,6-tetrahydro-6-oxo-2-pyridinecarboxylate; (R)-6-Oxo-1,6-dihydropyridine-2-carboxylic acid methyl ester; (R)-2-Carbomethoxy-1,2,3,6-tetrahydropyridin-6-one
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to stringent quality protocols suitable for pharmaceutical R&D and scale-up. Certificates of Analysis (COA) are provided with each batch, detailing critical parameters such as chiral purity (enantiomeric excess), chemical purity, and identity confirmation. We employ advanced analytical techniques including HPLC, GC, and chiral chromatography to ensure batch-to-batch consistency and compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.