Description

Ethyl 2-Fluoro-4-Methoxybenzoylacetate is a high-purity fluorinated aromatic ester building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both fluorine and methoxy substituents, makes it a versatile precursor for constructing complex pharmacophores and functional materials. This compound is primarily utilized by research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in central nervous system (CNS) and anti-inflammatory research.
• Agrochemical Synthesis: Used as a precursor in developing novel herbicides and pesticides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a starting material for synthesizing fluorinated aromatic cores used in electronic display and lighting technologies.
• Advanced Polymer Chemistry: Employed to introduce fluorine-containing moieties into polymer backbones to modify thermal, chemical, and surface properties.
• Chemical Research & Development: A valuable reagent for method development and exploring new fluorination reactions and coupling methodologies in academic and industrial labs.
• Custom Synthesis & Contract Manufacturing: Supplied for bespoke synthesis projects requiring specific fluorinated aromatic intermediates.

Basic Information

Product Name	Ethyl 2-Fluoro-4-Methoxybenzoylacetate
CAS No.	188182-79-8
Molecular Formula	C₁₂H₁₃FO₄
Molecular Weight	240.23 g/mol
Synonyms	Ethyl (2-Fluoro-4-methoxyphenyl)-3-oxopropanoate; 3-Oxo-3-(2-fluoro-4-methoxyphenyl)propanoic Acid Ethyl Ester; Acetic Acid, (2-Fluoro-4-methoxybenzoyl)-, Ethyl Ester; Ethyl 3-(2-Fluoro-4-methoxyphenyl)-3-oxopropanoate; 2-Fluoro-4-methoxybenzoylacetic Acid Ethyl Ester; Ethyl 2-Fluoro-4-methoxy-β-oxobenzenepropanoate; Ethyl (2-Fluoro-4-methoxybenzoyl)acetate
EINECS	Contact for details

Quality Control

Our Ethyl 2-Fluoro-4-Methoxybenzoylacetate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the stringent requirements of advanced synthetic applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation by atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.