Description

(R)-(-)-1-n-Boc-3-Aminopiperidine is a high-purity, chiral piperidine derivative that serves as a critical building block in modern organic synthesis. Its value lies in providing a protected, stereochemically defined amine and piperidine scaffold essential for constructing complex molecules. This compound is primarily needed by pharmaceutical and biotechnology R&D teams for the development of active pharmaceutical ingredients (APIs), particularly in creating chiral amines for drug candidates targeting neurological and metabolic disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, especially those requiring a stereochemically pure piperidine core.
• API Development: Used in research and process chemistry for constructing active pharmaceutical ingredients (APIs) with specific stereochemistry.
• Asymmetric Synthesis: Serves as a chiral auxiliary or starting material in catalytic asymmetric reactions to introduce stereocenters.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization for fine-tuning drug properties.
• Peptidomimetics & Bioactive Molecules: Integral for designing and synthesizing peptide mimics and other bioactive compounds that interact with biological targets.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up services for the life sciences industry.

Basic Information

Product Name	(R)-(-)-1-n-Boc-3-Aminopiperidine
CAS No.	188111-79-1
Molecular Formula	C10H20N2O2
Molecular Weight	200.28 g/mol
Synonyms	(R)-1-Boc-3-Aminopiperidine; (R)-3-Amino-1-Boc-piperidine; (R)-1-(tert-Butoxycarbonyl)-3-aminopiperidine; (R)-N-Boc-3-piperidinamine; (R)-3-Amino-1-(tert-butoxycarbonyl)piperidine; tert-Butyl (R)-3-aminopiperidine-1-carboxylate; (R)-(-)-1-tert-Butoxycarbonyl-3-aminopiperidine; (R)-1-N-Boc-3-aminopiperidine
EINECS	Contact for details

Quality Control

Our (R)-(-)-1-n-Boc-3-Aminopiperidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, chiral purity (enantiomeric excess), and impurity profiles. Our quality commitment aligns with the standards expected for pharmaceutical intermediates, supporting our clients' regulatory and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.