Description

Methyl n-Boc-4-Hydroxypiperidine-2-Carboxylate CAS NO 187753-13-5 is a high-purity, protected amino acid derivative widely used as a critical chiral building block in advanced organic synthesis. This compound is essential for constructing complex molecular architectures with precise stereochemistry, offering researchers and manufacturers a reliable and versatile intermediate. It is primarily utilized by the pharmaceutical, agrochemical, and fine chemical industries for the development of active pharmaceutical ingredients (APIs), novel agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel drug candidates, particularly for central nervous system (CNS) and antiviral therapies.
• Peptidomimetic Synthesis: Serves as a constrained, proline-like building block for designing and synthesizing peptide analogs and peptidomimetics with enhanced metabolic stability.
• Agrochemical Development: Used in the synthesis of advanced, optically active herbicides, fungicides, and plant growth regulators.
• Catalyst and Ligand Preparation: Employed in the synthesis of chiral catalysts and ligands for asymmetric synthesis applications.
• Academic and R&D: A valuable reagent for medicinal chemistry research, process development, and exploring new synthetic methodologies in university and industrial laboratories.
• Fine Chemical Production: Integral to the manufacture of complex, high-value specialty chemicals and custom synthesis projects.

Basic Information

Product Name	Methyl n-Boc-4-Hydroxypiperidine-2-Carboxylate
CAS No.	187753-13-5
Molecular Formula	C13H23NO6
Molecular Weight	289.33 g/mol
Synonyms	Methyl 1-(tert-Butoxycarbonyl)-4-hydroxypiperidine-2-carboxylate; 1-Boc-4-Hydroxy-2-piperidinecarboxylic Acid Methyl Ester; Methyl 4-Hydroxy-1-[(2-methyl-2-propanyl)oxycarbonyl]-2-piperidinecarboxylate; 1-N-Boc-4-Hydroxypipecolic Acid Methyl Ester; 4-Hydroxy-1-Boc-pipecolic Acid Methyl Ester; Methyl (2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxypiperidine-2-carboxylate (for specific stereoisomers); Boc-4-Hydroxy-DL-pipecolic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our Methyl n-Boc-4-Hydroxypiperidine-2-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical and advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (for enantiopure grades)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.