Description

Fmoc-Asp-Ofm CAS NO 187671-16-5 is a protected aspartic acid derivative, specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for the controlled incorporation of aspartic acid into peptide chains, preventing unwanted side reactions during the assembly process. It is an essential building block for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors developing therapeutic peptides, diagnostic agents, and complex biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated, sequential construction of peptide sequences.
• Pharmaceutical Intermediate: Used in the research and development of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Bioconjugation: Serves as a precursor for creating peptide-protein or peptide-small molecule conjugates for targeted therapies.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive compounds.
• Biochemical Research: Utilized in academic and industrial labs to study protein structure, function, and interactions.
• Production of Custom Peptides: Essential for contract research and manufacturing organizations (CROs/CMOs) offering bespoke peptide services.

Basic Information

Product Name	Fmoc-Asp-Ofm
CAS No.	187671-16-5
Molecular Formula	C24H25NO6
Molecular Weight	423.46 g/mol
Synonyms	Fmoc-L-aspartic acid β-tert-butyl ester; Fmoc-Asp(OtBu)-OH; N-(9-Fluorenylmethoxycarbonyl)-L-aspartic acid 4-tert-butyl ester; Fmoc-L-Asp(OtBu)-OH; Nα-Fmoc-L-aspartic acid 4-tert-butyl ester; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]butanedioic acid 4-tert-butyl ester; Fmoc-Asp(OtBu)-OH; Fmoc-Aspartate(OtBu)
EINECS	Contact for details

Quality Control

Our Fmoc-Asp-Ofm is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.