Description

3,3,3-Trifluoro-2-Hydroxy-2-Phosphonopropionic Acid Methyl Ester is a high-value organophosphorus compound containing both phosphonic acid and trifluoromethyl functional groups. This unique structure makes it a versatile and critical building block for advanced synthesis in pharmaceutical and agrochemical research. It is primarily sought by R&D and process development teams for the creation of novel active ingredients, particularly as a precursor for bisphosphonate analogs and other biologically active molecules. Its commercial value lies in enabling the introduction of fluorine and phosphonate motifs, which are key to modulating the potency, stability, and metabolic profile of target compounds.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel bisphosphonate drugs targeting bone disorders (e.g., osteoporosis) and other therapeutic areas.
• Agrochemical Research: Used in the synthesis of herbicidal and plant growth regulator candidates, leveraging the bioactivity of phosphonate groups.
• Ligand & Catalyst Precursor: Serves as a starting material for creating specialized phosphonate-based ligands used in asymmetric catalysis and metal complexation.
• Chemical Biology Probe Development: Employed to incorporate stable phosphonate mimics of phosphate esters into molecules for studying enzymatic processes.
• Material Science: Potential monomer or additive for creating specialty polymers with unique surface properties or flame retardancy.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke chemical synthesis projects requiring this specific fluorinated phosphonate ester.

Basic Information

Product Name	3,3,3-Trifluoro-2-Hydroxy-2-Phosphonopropionic Acid Methyl Ester
CAS No.	187653-39-0
Molecular Formula	C4H6F3O6P
Molecular Weight	238.06 g/mol
Synonyms	Methyl 3,3,3-trifluoro-2-hydroxy-2-phosphonopropionate; 2-Hydroxy-3,3,3-trifluoro-2-phosphonopropionic acid methyl ester; (3,3,3-Trifluoro-2-hydroxy-2-phosphono-propionic acid) methyl ester; Methyl (3,3,3-trifluoro-2-hydroxy-2-phosphono)propanoate; 3,3,3-Trifluoro-2-hydroxy-2-phosphono-propionic acid methyl ester; TFHP Methyl Ester; 187653-39-0; Propanoic acid, 3,3,3-trifluoro-2-hydroxy-2-phosphono-, methyl ester
EINECS	Contact for details

Quality Control

Every batch of 3,3,3-Trifluoro-2-Hydroxy-2-Phosphonopropionic Acid Methyl Ester is produced and analyzed under a strict quality management system. We employ advanced analytical techniques including HPLC, NMR (¹H, ¹⁹F, ³¹P), and GC-MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment, and we support customer audits and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.