Description

Cyclopropanecarboxaldehyde, 2-[(Trimethylsilyl)Methyl]-, cis- (9Ci) is a specialized organosilicon building block featuring a reactive aldehyde group on a cis-substituted cyclopropane ring. This compound matters for its unique three-dimensional structure and functional group combination, enabling the synthesis of complex, sterically defined molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for advanced intermediate synthesis and medicinal chemistry applications.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the cyclopropane moiety can impart specific biological activity and stability.
• Material Science Research: Acts as a precursor for synthesizing functionalized silanes and silicon-containing polymers with tailored properties.
• Asymmetric Catalysis: Employed as a substrate or ligand precursor in the development of new asymmetric catalytic reactions due to its defined stereochemistry.
• Chemical Biology Probes: Utilized to create molecular probes for studying enzyme mechanisms or protein interactions, leveraging the aldehyde for bioconjugation.
• Flavor & Fragrance Chemistry: Investigated for the synthesis of novel aroma compounds with unique structural motifs derived from the cyclopropane ring.

Basic Information

Product Name	Cyclopropanecarboxaldehyde, 2-[(Trimethylsilyl)Methyl]-, cis- (9Ci)
CAS No.	187335-52-0
Molecular Formula	C8H16OSi
Molecular Weight	156.30 g/mol
Synonyms	cis-2-[(Trimethylsilyl)methyl]cyclopropanecarboxaldehyde; cis-2-((Trimethylsilyl)methyl)cyclopropanecarbaldehyde; (1S,2R)-2-[(Trimethylsilyl)methyl]cyclopropanecarboxaldehyde (for specific enantiomer); TMSMCPCA; Cyclopropanecarboxaldehyde, 2-[(trimethylsilyl)methyl]-, (1R,2S)-rel-; Organosilicon cyclopropane aldehyde; Trimethylsilylmethyl cyclopropanecarboxaldehyde
EINECS	Contact for details

Quality Control

Our Cyclopropanecarboxaldehyde, 2-[(Trimethylsilyl)Methyl]-, cis- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by GC or HPLC, to ensure high chemical and isomeric purity suitable for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and purity. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0%
Chiral Purity (Chiral GC/HPLC)	≥ 98.0% cis-isomer
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.