Description

Bimosiamose is a potent and selective small-molecule antagonist of sialyl Lewis X (sLex) and related E-selectin ligands. This compound matters for its critical role in modulating inflammatory processes by inhibiting leukocyte adhesion and migration, a key pathway in numerous disease states. It is primarily needed by researchers and developers in the pharmaceutical and biotechnology sectors for investigating and developing novel therapeutics targeting inflammatory diseases, ischemia-reperfusion injury, and certain cancers.

Application

• Inflammatory Disease Research: A key tool for studying the role of E-selectin mediated adhesion in conditions like asthma, rheumatoid arthritis, and psoriasis.
• Oncology Research: Investigation of metastasis inhibition, as selectin-mediated interactions are involved in cancer cell adhesion and spreading.
• Ischemia-Reperfusion Injury Studies: Evaluation of therapeutic potential in myocardial infarction, stroke, and organ transplant scenarios.
• Drug Discovery & Development: Serves as a reference compound or lead structure for developing novel anti-inflammatory and anti-adhesive agents.
• Biochemical Assays: Used in in vitro and cell-based assays to specifically block E-selectin binding and downstream signaling pathways.
• Academic & Preclinical Research: Fundamental research into leukocyte biology, vascular inflammation, and cell adhesion mechanisms.

Basic Information

Product Name	Bimosiamose
CAS No.	187269-40-5
Molecular Formula	C19H33NO8S
Molecular Weight	435.54 g/mol
Synonyms	1,6-Bis(3-deoxy-3-[[(4-methylphenyl)sulfonyl]amino]-β-D-galactopyranos-6-yloxy)hexane; TBC-1269; Bimosiamose disodium; Bimosiamose (free acid); E-Selectin Antagonist; sLex Mimetic; Selectin Antagonist
EINECS	Contact for details

Quality Control

Our Bimosiamose is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.