Description

1-Azaspiro[4.4]Nonan-2-One,6-Hydroxy-,trans-(9Ci) is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic structure. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral research. It is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries seeking to develop novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic targets.
• Process Chemistry: Serves as a starting material or intermediate in the scalable synthesis of complex organic molecules under GMP conditions.
• CNS Drug Development: Particularly relevant in the synthesis of compounds targeting neurological pathways.
• Antiviral Agent Synthesis: Utilized in the construction of spirocyclic scaffolds found in certain antiviral medications.
• Academic & Contract Research: Employed in university and CRO laboratories for exploratory synthetic chemistry and method development.

Basic Information

Product Name	1-Azaspiro[4.4]Nonan-2-One,6-Hydroxy-,trans-(9Ci)
CAS No.	187106-20-3
Molecular Formula	C8H13NO2
Molecular Weight	155.19 g/mol
Synonyms	trans-6-Hydroxy-1-azaspiro[4.4]nonan-2-one; (3R,6R)-6-Hydroxy-1-azaspiro[4.4]nonan-2-one; 6-Hydroxy-1-azaspiro[4.4]nonan-2-one, trans-; 1-Azaspiro[4.4]nonan-2-one, 6-hydroxy-, (3R,6R)-; 187106-20-3; trans-6-Hydroxy-1-azaspiro[4,4]nonan-2-one
EINECS	Contact for details

Quality Control

Our 1-Azaspiro[4.4]Nonan-2-One,6-Hydroxy-,trans-(9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity and impurity profile analysis by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Any single impurity ≤ 0.5%; Total impurities ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.