Description

D-Proline, 1,3-Dimethyl-, Methyl Ester, (3S)-Rel- (9Ci) is a high-purity, non-natural proline derivative that serves as a critical chiral building block and intermediate in advanced organic synthesis. Its value lies in providing a sterically defined, enantiomerically enriched scaffold for constructing complex molecules with precise stereochemistry. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients, peptide mimetics, and chiral catalysts.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of protease inhibitors, receptor antagonists, and other bioactive molecules.
• Peptidomimetics Research: Used to introduce constrained proline analogs into peptide backbones to enhance metabolic stability and conformational rigidity.
• Asymmetric Catalysis: Employed as a precursor or ligand in the development of chiral catalysts for enantioselective transformations.
• Agrochemical Synthesis: Building block for creating chiral active ingredients with specific biological activity.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes to study enzyme mechanisms and protein-protein interactions.
• Academic & Process R&D: Serves as a valuable starting material for methodological development and scale-up studies in synthetic chemistry.

Basic Information

Product Name	D-Proline, 1,3-Dimethyl-, Methyl Ester, (3S)-Rel- (9Ci)
CAS No.	186653-16-7
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	(3S)-rel-1,3-Dimethyl-D-proline methyl ester; Methyl (3S)-rel-1,3-dimethyl-D-prolinate; Methyl (2S,3S)-1,3-dimethylpyrrolidine-2-carboxylate (relative configuration); D-1,3-Dimethylproline methyl ester; (3S)-1,3-Dimethyl-D-proline methyl ester; Proline, 1,3-dimethyl-, methyl ester, (3S)-rel-; Methyl 1,3-dimethyl-D-prolinate
EINECS	Contact for details

Quality Control

Our D-Proline, 1,3-Dimethyl-, Methyl Ester, (3S)-Rel- (9Ci) is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, chiral purity (enantiomeric excess), and identity confirmation. Certificates of Analysis (COA) detailing all specifications are available for every batch upon request, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.