Description

3-Pyridinamine,5-[(2R)-2-Azetidinylmethoxy]-2-Fluoro-(9Ci) is a sophisticated chiral building block and advanced pharmaceutical intermediate. This compound matters for its precise stereochemistry and functional group arrangement, which are critical for developing targeted bioactive molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for synthesizing novel drug candidates and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to explore novel chemical space due to its azetidine and fluoropyridine motifs.
• Process Chemistry & Scale-Up: Serves as a critical starting material or intermediate in the pilot-scale and commercial-scale synthesis of complex molecules.
• Agrochemical Development: Employed in the discovery and synthesis of new generation herbicides and pesticides with improved efficacy and selectivity.
• Ligand & Catalyst Design: The structural features make it a candidate for developing novel chiral ligands or organocatalysts for asymmetric synthesis.
• Reference Standard: Used as a high-purity analytical standard for quality control and regulatory filing (e.g., FDA, EMA) of finished APIs.

Basic Information

Product Name	3-Pyridinamine,5-[(2R)-2-Azetidinylmethoxy]-2-Fluoro-(9Ci)
CAS No.	186590-44-3
Molecular Formula	C9H12FN3O
Molecular Weight	197.21 g/mol
Synonyms	2-Fluoro-5-[(2R)-2-azetidinylmethoxy]-3-pyridinamine; (R)-2-((5-Amino-6-fluoropyridin-3-yloxy)methyl)azetidine; 5-[(2R)-2-Azetidinylmethoxy]-2-fluoro-3-pyridinamine; 186590-44-3; (R)-2-((5-Amino-6-fluoropyridin-3-yl)oxymethyl)azetidine; Azetidine, 2-((5-amino-6-fluoro-3-pyridinyloxy)methyl)-, (2R)-; 3-Pyridinamine, 5-[(2R)-2-azetidinylmethoxy]-2-fluoro-
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized using advanced analytical techniques including HPLC, GC, NMR, and MS to confirm identity, purity, and chiral integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your R&D and regulatory needs. We adhere to a cGMP-compliant quality management system for traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the material should be handled under a dry inert atmosphere (e.g., nitrogen or argon) and stored with appropriate desiccants. Recommended long-term storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.