Description

4-Bromo-2-(Trifluoromethyl)Phenyl Isocyanate is a versatile and highly reactive aromatic isocyanate building block, essential for synthesizing advanced chemical intermediates. Its core value lies in the unique combination of bromine and trifluoromethyl substituents, which enable precise structural modifications and the introduction of valuable physicochemical properties into target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting enzyme inhibitors and receptor modulators.
• Agrochemical Synthesis: Used to construct advanced active ingredients for crop protection products, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Polymer & Material Science: Serves as a monomer or cross-linking agent for producing specialized polyurethanes, polyureas, and other polymers with tailored thermal and chemical resistance.
• Ligand & Catalyst Development: Employed in the creation of sophisticated ligands for catalysis and metal-organic frameworks (MOFs), where the bromine atom allows for further functionalization.
• Chemical Research & Development: A critical reagent for exploring new chemical spaces and developing novel heterocyclic compounds in academic and industrial R&D settings.

Basic Information

Product Name	4-Bromo-2-(Trifluoromethyl)Phenyl Isocyanate
CAS No.	186589-12-8
Molecular Formula	C8H3BrF3NO
Molecular Weight	266.02 g/mol
Synonyms	1-Bromo-4-isocyanato-2-(trifluoromethyl)benzene; 4-Bromo-α,α,α-trifluoro-o-tolyl isocyanate; 2-Trifluoromethyl-4-bromophenyl isocyanate; 4-Bromo-2-trifluoromethylphenyl isocyanate; Isocyanic acid, 4-bromo-2-(trifluoromethyl)phenyl ester; 4-Bromo-α,α,α-trifluoro-2-isocyanatotoluene
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-(Trifluoromethyl)Phenyl Isocyanate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment supports your compliance needs for research and commercial-scale synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation by atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.