Description

(2S,3R)-cis-3-Methyl-L-Proline Ethyl Ester is a high-purity, non-natural proline derivative characterized by its specific stereochemistry. This compound matters as a crucial chiral building block and intermediate in advanced organic synthesis, enabling the construction of complex molecules with precise three-dimensional control. It is primarily needed by pharmaceutical R&D and fine chemical manufacturers for applications in peptide mimetics, drug discovery, and the synthesis of bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other targeted therapies.
• Peptidomimetics & Constrained Peptides: Used to introduce conformational constraints into peptide backbones, enhancing metabolic stability and biological activity for novel drug candidates.
• Asymmetric Synthesis: Serves as a chiral auxiliary or starting material in catalytic and stoichiometric asymmetric reactions to induce stereoselectivity.
• Medicinal Chemistry & SAR Studies: Employed to explore structure-activity relationships by modifying the proline scaffold in lead optimization programs.
• Bioconjugation & Linker Chemistry: Potential use in constructing specialized linkers for antibody-drug conjugates (ADCs) or prodrug strategies due to its ester functionality.
• Academic & Institutional Research: A valuable reagent for synthetic methodology development and biochemical studies in university and institutional laboratories.

Basic Information

Product Name	(2S,3R)-cis-3-Methyl-L-Proline Ethyl Ester
CAS No.	186586-71-0
Molecular Formula	C9H17NO3
Molecular Weight	187.24 g/mol
Synonyms	L-Proline, 3-methyl-, ethyl ester, (2S,3R)-; (2S,3R)-3-Methylproline ethyl ester; Ethyl (2S,3R)-3-methyl-L-prolinate; cis-3-Methyl-L-proline ethyl ester; (2S,3R)-cis-3-Methylproline ethyl ester; Ethyl (2S,3R)-3-methylpyrrolidine-2-carboxylate; (2S,3R)-3-Methyl-L-proline ethyl ester; 186586-71-0
EINECS	Contact for details

Quality Control

Our (2S,3R)-cis-3-Methyl-L-Proline Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for sensitive pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive); ensure containers are sealed under an inert atmosphere after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.