Description

Diethyl (1-Cyano-3-Methylbutyl)Malonate is a versatile malonate ester derivative, serving as a critical chiral building block and synthetic intermediate in advanced organic synthesis. Its value lies in the strategic combination of a reactive cyano group and ester functionalities, enabling the construction of complex molecular architectures with high stereochemical control. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for the development of active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug molecules, including potential antiviral and central nervous system (CNS) agents.
• Fine Chemical Synthesis: Used in the preparation of specialty chemicals, agrochemicals, and advanced materials requiring specific stereochemistry.
• Asymmetric Synthesis: Employed in reactions catalyzed by chiral catalysts or enzymes to produce enantiomerically pure compounds.
• Peptidomimetic Research: Serves as a precursor for non-natural amino acids and peptide analogs used in medicinal chemistry.
• Chemical Building Block: Utilized in multi-step synthetic routes for constructing complex heterocycles and natural product analogs.

Basic Information

Product Name	Diethyl (1-Cyano-3-Methylbutyl)Malonate
CAS No.	186038-82-4
Molecular Formula	C₁₃H₂₁NO₄
Molecular Weight	255.31 g/mol
Synonyms	Diethyl 1-Cyano-3-methylbutylmalonate; 1-Cyano-3-methylbutylmalonic Acid Diethyl Ester; (1-Cyano-3-methylbutyl)propanedioic Acid Diethyl Ester; Malonic Acid, (1-Cyano-3-methylbutyl)-, Diethyl Ester; Diethyl (1-Cyano-3-methylbutyl)propanedioate; 186038-82-4; (1-Cyano-3-methylbutyl)malonic Acid Diethyl Ester
EINECS	Contact for details

Quality Control

Our Diethyl (1-Cyano-3-Methylbutyl)Malonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 98.0% ee (or as specified)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.