Description

O O'Bis(2-(n-Succinimidyl-Succinylamino) Ethyl) Polyethylene Glycol is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative designed for advanced bioconjugation and crosslinking applications. This compound is critical for creating stable, well-defined linkages between biomolecules, such as proteins and peptides, while maintaining their biological activity. It is an essential reagent for researchers and manufacturers in pharmaceutical development, diagnostics, and life sciences, particularly for PEGylating therapeutic agents to improve pharmacokinetics and reduce immunogenicity.

Application

• Protein and Antibody PEGylation: Conjugation to therapeutic proteins and monoclonal antibodies to enhance solubility, prolong circulation half-life, and reduce immunogenicity.
• Peptide Drug Conjugation: Modification of peptide-based pharmaceuticals to improve stability and bioavailability.
• Diagnostic Reagent Development: Crosslinking enzymes, antibodies, or other proteins to solid supports or signal-generating molecules in assay kits.
• Biomaterial Surface Modification: Functionalizing medical device surfaces or nanoparticles with bioactive molecules to improve biocompatibility and targeting.
• Linker for ADC (Antibody-Drug Conjugate) Payloads: Serving as a cleavable or non-cleavable spacer between the antibody and cytotoxic drug in ADC development.
• Crosslinking Agent for Hydrogel Formation: Creating biocompatible hydrogels for drug delivery systems and tissue engineering scaffolds.

Basic Information

Product Name	O O'Bis(2-(n-Succinimidyl-Succinylamino) Ethyl) Polyethylene Glycol
CAS No.	186020-53-1
Molecular Formula	Contact for details
Molecular Weight	Variable (based on PEG chain length, n)
Synonyms	Bis-Succinimidyl PEG
NHS-PEG-NHS
Disuccinimidyl PEG
DSPEG
Poly(ethylene glycol) bis(succinimidyl succinate)
PEG-bis(NHS ester)
O,O'-Bis[2-(N-succinimidylsuccinylamino)ethyl]polyethylene glycol
EINECS	Contact for details

Quality Control

Our O O'Bis(2-(n-Succinimidyl-Succinylamino) Ethyl) Polyethylene Glycol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and functional group assay, NMR for structural confirmation, and GPC for molecular weight distribution. Certificates of Analysis (COA) detailing all specifications are available upon request to ensure compliance with your research and development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and hydrolysis of the active NHS ester groups.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Functional Group Assay (NHS Ester)	≥ 90% of theoretical
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.