Description

2,3-Dichloro-5-Fluoropyridine is a high-purity halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its unique reactivity profile, where the strategic placement of chlorine and fluorine atoms enables selective functionalization. It is primarily sought after by R&D and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients, including herbicides, fungicides, and pharmaceutical intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecules in drug discovery and development, particularly for candidates targeting central nervous system and anti-infective applications.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides and fungicides, where the pyridine core contributes to biological activity and environmental profile.
• Material Science Precursor: Employed in the synthesis of functionalized ligands for catalysis and as a monomer or modifier in specialty polymer research.
• Cross-Coupling Reactions: Serves as an excellent substrate for Suzuki, Stille, and Negishi cross-coupling reactions to introduce the pyridine moiety into more complex structures.
• Nucleophilic Aromatic Substitution: The chlorine atoms at the 2 and 3 positions are amenable to displacement with various nucleophiles, enabling diverse derivatization.
• Fluorine Chemistry Research: Provides a stable platform for studying the influence of fluorine substitution on the physicochemical properties of heterocyclic compounds.

Basic Information

Product Name	2,3-Dichloro-5-Fluoropyridine
CAS No.	185985-40-4
Molecular Formula	C5H2Cl2FN
Molecular Weight	165.98 g/mol
Synonyms	5-Fluoro-2,3-dichloropyridine; 2,3-Dichloro-5-fluoropyridine; 2,3-Dichloro-5-fluoro-pyridine; Pyridine, 2,3-dichloro-5-fluoro-; 185985-40-4; 5-Fluoro-2,3-dichloro-pyridine; 2,3-Dichloro-5-fluoro pyridine
EINECS	Contact for details

Quality Control

Every batch of 2,3-Dichloro-5-Fluoropyridine is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and purity. Our standard grade typically meets a purity specification of ≥98% (by HPLC), with detailed impurity profiling available. A comprehensive Certificate of Analysis (COA) documenting identity, purity, and related substances is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and strong oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.