Description

Eritoran CAS NO 185955-34-4 is a synthetic lipid A analog and a potent antagonist of Toll-like receptor 4 (TLR4). This compound is of significant interest in advanced pharmaceutical research and development due to its targeted mechanism of action. It is primarily utilized by researchers and developers in the biopharmaceutical industry, particularly for investigating novel therapeutic approaches in immunology and inflammation.

Application

• Pharmaceutical Research & Development: As a key TLR4 antagonist for studying sepsis, inflammatory diseases, and autoimmune disorders.
• Immunology Studies: Used in vitro and in vivo to modulate innate immune responses and understand TLR4 signaling pathways.
• Preclinical Development: Serves as a reference standard or active pharmaceutical ingredient (API) in the development of anti-inflammatory and immunomodulatory therapeutics.
• Biochemical Assays: Employed as a critical reagent in high-throughput screening and target validation assays related to endotoxin-mediated signaling.
• Academic Research: Utilized in university and institutional labs for fundamental research on host-pathogen interactions and inflammation.

Basic Information

Product Name	Eritoran
CAS No.	185955-34-4
Molecular Formula	C94H172N2O23P2
Molecular Weight	1767.3 g/mol
Synonyms	Eritoran tetrasodium; E5564; Lipid A analog E5564; TLR4 antagonist E5564; ((2R)-2-{[(3R)-3-(Dodecanoyloxy)tetradecanoyl]amino}-3-{[(2S,3R,4R,5S,6R)-4-{[(2S,3R)-3-(dodecanoyloxy)tetradecanoyl]oxy}-3-{[(2S,3R)-3-hydroxytetradecanoyl]oxy}-5-{[(2S,3R,5R,6S)-3-{[(2S,3R)-3-hydroxytetradecanoyl]oxy}-6-(hydroxymethyl)-5-{[(2S,3R,5R)-3-{[(2S,3R)-3-hydroxytetradecanoyl]oxy}-5-(phosphonooxy)oxan-2-yl]oxy}oxan-2-yl]oxy}-6-(phosphonooxymethyl)oxan-2-yl]oxy}propyl 2-aminoethyl hydrogen phosphate)
EINECS	Contact for details

Quality Control

Our Eritoran is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods, and stringent controls for residual solvents and impurities. Certificates of Analysis (COA) are available upon request, detailing compliance with relevant specifications for research-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic nature, the container should be allowed to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.