Description

Tofimilast CAS NO 185954-27-2 is a selective phosphodiesterase 4 (PDE4) inhibitor, representing a significant class of compounds in modern pharmaceutical research. Its primary value lies in its potent anti-inflammatory and immunomodulatory properties, making it a key intermediate or active pharmaceutical ingredient (API) for targeted therapeutic development. This compound is essential for pharmaceutical companies and research institutions focused on developing novel treatments for chronic inflammatory diseases, such as chronic obstructive pulmonary disease (COPD), psoriasis, and atopic dermatitis.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of advanced PDE4 inhibitor drug candidates.
• Anti-inflammatory Drug Research: Used as a reference standard or active component in preclinical and clinical research for inflammatory airway diseases.
• Immunology Studies: Employed in biochemical assays to study PDE4 enzyme activity and intracellular cAMP signaling pathways.
• API Development: Acts as the core active ingredient in the formulation development of new anti-inflammatory medications.
• Dermatological Research: Investigated for potential topical or systemic applications in treating skin conditions driven by inflammation.

Basic Information

Product Name	Tofimilast
CAS No.	185954-27-2
Molecular Formula	C21H21N3O4S
Molecular Weight	411.47 g/mol
Synonyms	9-Cyclopentyl-7-ethyl-6,9-dihydro-5-methyl-6-oxo-3-(trifluoromethyl)-5H-pyrido[2,3-b]indole-8-carboxylic acid heptyl ester; Tofimilast free base; GRC 3886; PDE4 Inhibitor GRC 3886
EINECS	Contact for details

Quality Control

Our Tofimilast is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR), purity assessment by HPLC, and control of specified impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support development and commercial projects requiring standards aligned with cGMP and ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.