Description

Spirocyclohexane-1,2-1,3Dioxino4,5,6-Hiindolizin-9-Amine, 8-(1,1-Dimethylethyl)Dimethylsilyloxyoctahydro-, 3As-(3A.Alpha.,8.Alpha.,9.Beta.,9A.Beta.,9B.Alpha.)- CAS NO 185899-35-8 is a complex, high-purity spirocyclic organic compound featuring a protected amine and a silyl ether functional group. This specialized structure makes it a critical chiral intermediate for the synthesis of advanced pharmaceutical agents and fine chemicals. It is primarily sought after by research institutions and pharmaceutical development companies engaged in creating novel therapeutic molecules, particularly in areas requiring sophisticated stereochemical control.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of complex drug candidates, especially those targeting the central nervous system or with specific stereochemical requirements.
• Organic Synthesis Research: Used in academic and industrial R&D for developing new synthetic methodologies involving spirocyclic and heterocyclic frameworks.
• Asymmetric Catalysis: Potential use as a precursor or ligand in asymmetric synthesis due to its complex, three-dimensional chiral structure.
• Fine Chemical Production: Employed in the multi-step synthesis of high-value specialty chemicals and advanced materials.
• Reference Standard: Can be utilized as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	Spirocyclohexane-1,2-1,3Dioxino4,5,6-Hiindolizin-9-Amine, 8-(1,1-Dimethylethyl)Dimethylsilyloxyoctahydro-, 3As-(3A.Alpha.,8.Alpha.,9.Beta.,9A.Beta.,9B.Alpha.)-
CAS No.	185899-35-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	8-(tert-Butyldimethylsilyloxy)octahydrospiro[cyclohexane-1,2'-[1,3]dioxino[4,5,6-hi]indolizin]-9-amine (3aR,8R,9S,9aR,9bS)-isomer; (3aR,8R,9S,9aR,9bS)-8-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]octahydrospiro[cyclohexane-1,2'-[1,3]dioxino[4,5,6-hi]indolizin]-9-amine; Spiro[cyclohexane-1,2'-[1,3]dioxino[4,5,6-hi]indolizin]-9-amine, 8-[[(1,1-dimethylethyl)dimethylsilyl]oxy]octahydro-, (3aR,8R,9S,9aR,9bS)-; TBDMS-protected spirocyclic amine intermediate; CAS 185899-35-8.
EINECS	Contact for details

Quality Control

Our Spirocyclohexane-1,2-1,3Dioxino4,5,6-Hiindolizin-9-Amine intermediate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and chiral purity assessment, to meet the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is likely moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.