Description

Spirocyclohexane-1,2-1,3Dioxino4,5,6-Hiindolizin-9-Ol, 8-(1,1-Dimethylethyl)Dimethylsilyloxyoctahydro-, 3As-(3A.Alpha.,8.Alpha.,9.Alpha.,9A.Beta.,9B.Alpha.)- is a complex, high-purity spirocyclic organic compound with the CAS number 185899-32-5. This advanced chemical intermediate is valued for its unique stereochemistry and functional groups, which make it a critical building block in sophisticated synthetic pathways. It is primarily sought after by research and development teams in the pharmaceutical and fine chemical sectors for the synthesis of novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the research and development of new therapeutic agents, particularly for central nervous system (CNS) or anti-infective drugs.
• Advanced Organic Synthesis: Used as a specialized building block for constructing complex spirocyclic and polycyclic frameworks in academic and industrial research.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of high-value target molecules.
• Ligand and Catalyst Research: Potential utility in the development of novel chiral ligands or organocatalysts for asymmetric synthesis.
• Reference Standard: Supplied as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.

Basic Information

Product Name	Spirocyclohexane-1,2-1,3Dioxino4,5,6-Hiindolizin-9-Ol, 8-(1,1-Dimethylethyl)Dimethylsilyloxyoctahydro-, 3As-(3A.Alpha.,8.Alpha.,9.Alpha.,9A.Beta.,9B.Alpha.)-
CAS No.	185899-32-5
Molecular Formula	C22H37NO4Si
Molecular Weight	407.62 g/mol
Synonyms	8-(tert-Butyldimethylsilyloxy)octahydrospiro[cyclohexane-1,2'-[1,3]dioxino[4,5,6-hi]indolizin]-9-ol (3aR,8R,9R,9aR,9bR)-isomer; (3aR,8R,9R,9aR,9bR)-8-[(tert-Butyldimethylsilyl)oxy]octahydrospiro[cyclohexane-1,2'-[1,3]dioxino[4,5,6-hi]indolizin]-9-ol; tert-Butyldimethyl((3aR,8R,9R,9aR,9bR)-9-hydroxyoctahydrospiro[cyclohexane-1,2'-[1,3]dioxino[4,5,6-hi]indolizin]-8-yloxy)silane; CAS 185899-32-5; TBDMS-protected spirocyclic indolizinol; Advanced spirocyclic intermediate.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent GMP-like guidelines to ensure batch-to-batch consistency and traceability. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and MS to confirm identity, purity, and stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.