Description

(R)-2-Methylsuccinic Acid 4-tert-Butyl Ester is a high-purity chiral building block and synthetic intermediate of significant value in advanced organic synthesis. Its defined stereochemistry and protected carboxylic acid functionality make it a critical precursor for constructing complex molecules with precise three-dimensional architecture. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for developing active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of enantiomerically pure drugs and bioactive molecules.
• Asymmetric Synthesis: Used in the construction of complex natural products and other stereochemically defined targets.
• Peptidomimetics & Prodrug Development: Serves as a protected diacid fragment for designing peptide analogs and prodrug candidates.
• Ligand & Catalyst Synthesis: Employed in the preparation of chiral ligands for asymmetric catalysis and organocatalysts.
• Fine Chemical Production: A versatile intermediate for manufacturing specialty agrochemicals, flavors, and fragrances.
• Academic & Industrial R&D: Used in research laboratories for method development and exploring new synthetic pathways.

Basic Information

Product Name	(R)-2-Methylsuccinic Acid 4-tert-Butyl Ester
CAS No.	185836-75-3
Molecular Formula	C9H16O4
Molecular Weight	188.22 g/mol
Synonyms	(R)-4-(tert-Butoxy)-2-methyl-4-oxobutanoic Acid; (R)-2-Methylsuccinic Acid Mono-tert-butyl Ester; (R)-Mono-tert-butyl 2-methylsuccinate; (R)-1-tert-Butyl 4-Hydrogen 2-Methylsuccinate; (2R)-2-Methylbutanedioic Acid 4-tert-Butyl Ester; (R)-2-Methyl-4-(tert-butoxy)-4-oxobutanoic Acid; (R)-Mono-tert-butyl Methylsuccinate
EINECS	Contact for details

Quality Control

Our (R)-2-Methylsuccinic Acid 4-tert-Butyl Ester is produced under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized by advanced analytical techniques including chiral HPLC, NMR, and GC/MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profile is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.