Description

Carbamic Acid, [(2R)-2-Hydroxy-3-Methylbutyl]-, 1,1-Dimethylethyl Ester (9Ci) is a chiral, optically active carbamate derivative that serves as a critical synthetic intermediate in advanced organic synthesis. Its value lies in providing a protected amine and alcohol functionality, enabling the stereoselective construction of complex molecular architectures. This high-purity building block is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and production of active pharmaceutical ingredients (APIs), particularly in antiviral and protease inhibitor drug candidates.
• Agrochemical Synthesis: Used in the development of stereospecific pesticides and herbicides where the (R)-configuration is crucial for biological activity.
• Peptidomimetics & PROTACs: Serves as a versatile building block for constructing peptide backbones and linker components in proteolysis-targeting chimeras (PROTACs).
• Asymmetric Catalysis Ligand Precursor: Provides a scaffold for the synthesis of novel chiral ligands used in asymmetric hydrogenation and other catalytic transformations.
• Fine Chemical Research: Employed in academic and industrial R&D for exploring new synthetic methodologies and creating libraries of bioactive compounds.

Basic Information

Product Name	Carbamic Acid, [(2R)-2-Hydroxy-3-Methylbutyl]-, 1,1-Dimethylethyl Ester (9Ci)
CAS No.	185426-14-6
Molecular Formula	C10H21NO3
Molecular Weight	203.28 g/mol
Synonyms	tert-Butyl N-[(2R)-2-hydroxy-3-methylbutyl]carbamate; (2R)-2-Hydroxy-3-methylbutylcarbamic acid tert-butyl ester; (R)-tert-Butyl (2-hydroxy-3-methylbutyl)carbamate; N-Boc-(R)-2-Hydroxy-3-methylbutylamine; Boc-L-Valinol (common name based on structure); (R)-1-((tert-Butoxycarbonyl)amino)-3-methylbutan-2-ol; 185426-14-6; Carbamic acid, N-[(2R)-2-hydroxy-3-methylbutyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our Carbamic Acid, [(2R)-2-Hydroxy-3-Methylbutyl]-, 1,1-Dimethylethyl Ester (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP-grade synthesis. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm
Single Maximum Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.