Description

Methyl 2,6-Dichloro-3-Hydroxyisonicotinate is a high-purity, functionalized pyridine derivative serving as a critical synthetic intermediate. This compound matters for its role in constructing complex molecular architectures, particularly in advanced pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and fungicides, leveraging its halogenated pyridine core.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized ligands used in metal-catalyzed cross-coupling reactions.
• Material Science Research: Employed in the development of organic electronic materials and metal-organic frameworks (MOFs) due to its functional group diversity.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthetic projects.
• Academic and Institutional Research: Used in universities and research institutes for methodological studies in heterocyclic and medicinal chemistry.

Basic Information

Product Name	Methyl 2,6-Dichloro-3-Hydroxyisonicotinate
CAS No.	185422-98-4
Molecular Formula	C7H5Cl2NO3
Molecular Weight	222.03 g/mol
Synonyms	Methyl 2,6-dichloro-3-hydroxypyridine-4-carboxylate; 3-Hydroxy-2,6-dichloroisonicotinic acid methyl ester; 2,6-Dichloro-3-hydroxy-4-pyridinecarboxylic acid methyl ester; Methyl 3-hydroxy-2,6-dichloroisonicotinate; 4-Pyridinecarboxylic acid, 2,6-dichloro-3-hydroxy-, methyl ester; Methyl 2,6-dichloro-3-oxo-1,4-dihydropyridine-4-carboxylate (tautomeric form); 185422-98-4 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our Methyl 2,6-Dichloro-3-Hydroxyisonicotinate is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all test results are provided and available upon request, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.