Description

Proline, 4-Hydroxy-5-Oxo-, Methyl Ester (9Ci) is a specialized proline derivative, a key chiral building block and intermediate in advanced organic synthesis. Its unique structure, featuring both hydroxyl and oxo functional groups, makes it a valuable precursor for synthesizing complex molecules, particularly in pharmaceutical research. This compound is essential for chemists and manufacturers in the life sciences sector developing novel active pharmaceutical ingredients (APIs), peptidomimetics, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of novel Active Pharmaceutical Ingredients (APIs), particularly in oncology and metabolic disease research.
• Peptidomimetic Synthesis: Used in the design and construction of peptidomimetics and modified peptides to enhance stability, bioavailability, and biological activity.
• Asymmetric Synthesis: Serves as a chiral auxiliary or building block in stereoselective synthesis to create enantiomerically pure compounds.
• Bioconjugation & Probe Development: Utilized in the synthesis of chemical probes and bioconjugates for biochemical assays and diagnostic applications.
• Agrochemical Research: Acts as an intermediate in the development of new, targeted agrochemicals with specific modes of action.
• Academic & Industrial R&D: Employed in research laboratories for methodological development and exploring new chemical spaces in medicinal chemistry.

Basic Information

Product Name	Proline, 4-Hydroxy-5-Oxo-, Methyl Ester (9Ci)
CAS No.	185320-06-3
Molecular Formula	C7H11NO4
Molecular Weight	173.17 g/mol
Synonyms	Methyl 4-hydroxy-5-oxoproline; 4-Hydroxy-5-oxoproline methyl ester; 1-Methyl 4-hydroxy-5-oxo-L-prolinate; 5-Oxo-4-hydroxyproline methyl ester; 4-Hydroxy-5-oxo-L-proline methyl ester; Methyl (4R)-4-hydroxy-5-oxo-L-prolinate; L-Proline, 4-hydroxy-5-oxo-, methyl ester
EINECS	Contact for details

Quality Control

Our Proline, 4-Hydroxy-5-Oxo-, Methyl Ester (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for research and pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.