Description

3-Benzyloxy-2-Chloro-6-Iodopyridine is a high-purity halogenated pyridine derivative, serving as a versatile and critical building block in advanced organic synthesis. Its unique substitution pattern makes it an essential intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and functional materials. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for its role in cross-coupling reactions and as a scaffold for further functionalization.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially for kinase inhibitors and other biologically active heterocycles.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging its halogenated structure for bioactivity.
• Material Science: Serves as a building block for creating functional organic materials, including ligands for catalysis and components for organic electronics.
• Cross-Coupling Reactions: The iodine and chlorine substituents make it an excellent substrate for Suzuki, Stille, and Negishi couplings to introduce complex aryl and alkyl groups.
• Chemical Synthesis Research: Employed in academic and industrial R&D for method development and exploring new synthetic pathways.
• Ligand Synthesis: Used to prepare sophisticated pyridine-based ligands for transition metal catalysis.

Basic Information

Product Name	3-Benzyloxy-2-Chloro-6-Iodopyridine
CAS No.	185221-60-7
Molecular Formula	C12H9ClINO
Molecular Weight	345.56 g/mol
Synonyms	2-Chloro-3-benzyloxy-6-iodopyridine; 6-Iodo-2-chloro-3-(phenylmethoxy)pyridine; 3-(Benzyloxy)-2-chloro-6-iodopyridine; 2-Chloro-6-iodo-3-(phenylmethoxy)pyridine; Pyridine, 3-(benzyloxy)-2-chloro-6-iodo-; 185221-60-7; 3-Benzyloxy-2-chloro-6-iodopyridine
EINECS	Contact for details

Quality Control

Our 3-Benzyloxy-2-Chloro-6-Iodopyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent quality suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.