Description

(9H-Fluoren-9-Yl)Methoxy]Carbonyl D-Leu-Opfp CAS NO 184840-63-9 is a specialized, high-purity amino acid derivative used as a key building block in advanced organic synthesis. This compound is critical for researchers and manufacturers requiring precise stereochemistry and protecting group chemistry, particularly in the development of complex peptides and bioactive molecules. It is primarily utilized by the pharmaceutical, biotechnology, and advanced materials sectors for research, process development, and custom synthesis projects.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a protected D-leucine derivative with the Fmoc and OPfp groups, enabling controlled coupling in automated peptide assembly.
• Pharmaceutical Intermediate: A crucial precursor in the synthesis of peptide-based active pharmaceutical ingredients (APIs) and investigational new drugs.
• Bioconjugation & Probe Development: Used to incorporate D-amino acids or fluorinated tags into biomolecules for diagnostic and research applications.
• Custom Oligomer Synthesis: Employed in the research-scale production of non-natural peptides, peptidomimetics, and other oligomeric structures.
• Chemical Biology Research: Facilitates studies on protein structure, function, and interactions by allowing site-specific incorporation of modified amino acids.
• Process Development & Scale-Up: Supports process optimization and pilot-scale manufacturing for novel therapeutic candidates in GMP and non-GMP environments.

Basic Information

Product Name	(9H-Fluoren-9-Yl)Methoxy]Carbonyl D-Leu-Opfp
CAS No.	184840-63-9
Molecular Formula	C27H22F5NO5
Molecular Weight	535.46 g/mol
Synonyms	Fmoc-D-Leu-OPfp; Fmoc-D-Leucine Pentafluorophenyl Ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-leucine Pentafluorophenyl Ester; D-Leucine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, Pentafluorophenyl Ester; Fmoc-D-leucine pentafluorophenyl ester; Fmoc-D-Leu-OPfp Ester; N-Fmoc-D-leucine pentafluorophenyl ester; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-methylpentanoic acid 2,3,4,5,6-pentafluorophenyl ester
EINECS	Contact for details

Quality Control

Our (9H-Fluoren-9-Yl)Methoxy]Carbonyl D-Leu-Opfp is produced and tested under stringent quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥98% by HPLC), and impurity profiles. We adhere to relevant industry standards and can provide material suitable for use in GMP-regulated environments upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Allow the sealed container to reach ambient temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.