Description

2-Amino-3-(3H-Imidazol-4-Yl)-Propionic Acid Ethyl Ester is a high-purity, protected derivative of the amino acid histidine, serving as a critical building block in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring a reactive, esterified precursor for peptide coupling and medicinal chemistry applications. It is primarily utilized in pharmaceutical R&D for the synthesis of novel drug candidates, bioactive peptides, and complex heterocyclic molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing histidine-containing peptides and peptidomimetics with potential therapeutic activity.
• Medicinal Chemistry Research: Used in the design and development of novel drug candidates targeting various receptors and enzymes.
• Bioconjugation & Probe Synthesis: Serves as a starting material for creating fluorescent probes, affinity labels, and other bioconjugates for biochemical studies.
• Chemical Biology: Employed in the synthesis of modified amino acids and unnatural peptides to study protein structure and function.
• Academic & Industrial R&D: A valuable reagent for synthetic organic chemists in both university laboratories and industrial R&D departments.

Basic Information

Product Name	2-Amino-3-(3H-Imidazol-4-Yl)-Propionic Acid Ethyl Ester
CAS No.	184295-36-1
Molecular Formula	C9H13N3O2
Molecular Weight	195.22 g/mol
Synonyms	Ethyl 2-Amino-3-(1H-imidazol-4-yl)propanoate; Histidine Ethyl Ester; L-Histidine Ethyl Ester; 2-Amino-3-(1H-imidazol-5-yl)propanoic acid ethyl ester; 4-Imidazolepropanoic acid, α-amino-, ethyl ester; Ethyl 3-(1H-imidazol-4-yl)-2-aminopropanoate; Fmoc-His-OEt precursor; Histidine-OEt
EINECS	Contact for details

Quality Control

Our 2-Amino-3-(3H-Imidazol-4-Yl)-Propionic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.