Description

n-(tert-Butoxycarbonyl)-(3S)-Hydroxy-L-Proline Methyl Ester is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound serves as a critical chiral building block, enabling the precise construction of complex peptide structures with defined stereochemistry. It is primarily required by pharmaceutical R&D and production teams for the development of therapeutic peptides, peptidomimetics, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of peptide-based active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate hydroxyproline residues with Boc-protection.
• Protease Inhibitor Development: Serves as a precursor in the research and manufacturing of enzyme inhibitors targeting collagenases and other proteases.
• Bioconjugation & Labeling: Utilized for creating functionalized peptides for drug delivery systems, diagnostics, and bioconjugates.
• Chemical Biology Research: Employed in the study of protein-protein interactions and the design of novel bioactive probes.
• Cosmetic Peptide Synthesis: Used in the production of specialized peptides for advanced skincare and cosmetic formulations.

Basic Information

Product Name	n-(tert-Butoxycarbonyl)-(3S)-Hydroxy-L-Proline Methyl Ester
CAS No.	184046-78-4
Molecular Formula	C11H19NO5
Molecular Weight	245.27 g/mol
Synonyms	Boc-Hyp-OMe; (2S,4S)-1-(tert-Butoxycarbonyl)-4-hydroxy-2-pyrrolidinecarboxylic Acid Methyl Ester; Boc-trans-4-Hydroxy-L-proline Methyl Ester; Methyl (2S,4S)-1-[(2-methylpropan-2-yl)oxycarbonyl]-4-hydroxypyrrolidine-2-carboxylate; Boc-L-Hydroxyproline-OMe; (3S)-Hydroxy-L-Proline Methyl Ester, N-Boc-; N-Boc-trans-4-hydroxy-L-proline methyl ester; N-Boc-4(R)-Hydroxy-L-proline Methyl Ester
EINECS	Contact for details

Quality Control

Our n-(tert-Butoxycarbonyl)-(3S)-Hydroxy-L-Proline Methyl Ester is manufactured under strict quality systems to meet the stringent requirements of pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure high chemical and enantiomeric purity. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.