Description

5-(tert-Butoxycarbonylamino)-2-Methoxypyridine-4-Carboxylic Acid is a high-purity, protected amino acid derivative serving as a critical building block in advanced organic synthesis. This compound is essential for the development of novel active pharmaceutical ingredients (APIs) and complex molecules, offering a reactive carboxylic acid group and a Boc-protected amine for selective deprotection and further functionalization. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in medicinal chemistry, process development, and the synthesis of heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for kinase inhibitors and other small molecule therapeutics.
• Peptidomimetic Synthesis: Used to incorporate modified pyridine-based amino acid structures into peptide chains to enhance stability, bioavailability, or biological activity.
• Agrochemical Research: Serves as a precursor in the synthesis of novel herbicides, fungicides, and plant growth regulators with specific pyridine motifs.
• Ligand and Catalyst Development: Employed in the creation of specialized chelating ligands or organocatalysts for asymmetric synthesis and metal complexation.
• Material Science Precursor: Can be used to synthesize functionalized organic molecules for advanced materials, such as liquid crystals or organic semiconductors.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	5-(tert-Butoxycarbonylamino)-2-Methoxypyridine-4-Carboxylic Acid
CAS No.	183741-86-8
Molecular Formula	C12H16N2O5
Molecular Weight	268.27 g/mol
Synonyms	5-((tert-Butoxycarbonyl)amino)-2-methoxypyridine-4-carboxylic acid; 4-Pyridinecarboxylic acid, 5-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methoxy-; 5-(Boc-amino)-2-methoxypyridine-4-carboxylic acid; 5-(N-Boc-amino)-2-methoxypyridine-4-carboxylic acid; 2-Methoxy-5-(N-Boc-amino)isonicotinic acid; Boc-5-Amino-2-methoxyisonicotinic acid; 5-(tert-Butoxycarbonylamino)-2-methoxyisonicotinic acid
EINECS	Contact for details

Quality Control

Our 5-(tert-Butoxycarbonylamino)-2-Methoxypyridine-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light to maintain stability and purity. For long-term storage, consider using desiccants and storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.