Description

4,7-Methano-1,3-Dioxolo[4,5-C]Pyridine-5(4H)-Carboxylic Acid, Tetrahydro-2,2-Dimethyl-6-Oxo-, 1,1-Dimethylethyl Ester, (3As,4R,7S,7Ar)- is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound is a critical chiral building block valued for its complex, rigid bicyclic structure, which is essential for imparting specific biological activity in final drug molecules. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in areas requiring sophisticated molecular architecture.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and antiviral drugs.
• Medicinal Chemistry Research: Used in drug discovery and lead optimization programs to explore structure-activity relationships (SAR) due to its constrained conformation.
• Asymmetric Synthesis: Serves as a precursor or template in catalytic asymmetric reactions to construct complex molecules with high enantiomeric purity.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Contract Manufacturing (CMO/CDMO): Supplied to contract research and manufacturing organizations for custom synthesis projects under cGMP conditions.
• Academic Research: Utilized in university and institutional labs for methodological studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	4,7-Methano-1,3-Dioxolo[4,5-C]Pyridine-5(4H)-Carboxylic Acid, Tetrahydro-2,2-Dimethyl-6-Oxo-, 1,1-Dimethylethyl Ester, (3As,4R,7S,7Ar)-
CAS No.	183272-49-3
Molecular Formula	C15H21NO5
Molecular Weight	295.33 g/mol
Synonyms	(3aS,4R,7S,7aR)-Tetrahydro-2,2-dimethyl-6-oxo-4,7-methano-1,3-dioxolo[4,5-c]pyridine-5(4H)-carboxylic acid tert-butyl ester; tert-Butyl (3aS,4R,7S,7aR)-tetrahydro-2,2-dimethyl-6-oxo-4,7-methano-1,3-dioxolo[4,5-c]pyridine-5(4H)-carboxylate; (3aS,4R,7S,7aR)-rel-5-(1,1-Dimethylethyl) 4,7-Methano-1,3-dioxolo[4,5-c]pyridine-5,6(4H)-dicarboxylate; Bicyclic Proline Derivative; Advanced Chiral Lactam Ester.
EINECS	Contact for details

Quality Control

Our 4,7-Methano-1,3-Dioxolo[4,5-C]Pyridine-5(4H)-Carboxylic Acid, Tetrahydro-2,2-Dimethyl-6-Oxo-, 1,1-Dimethylethyl Ester, (3As,4R,7S,7Ar)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support development with custom purity grades and analytical method development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.