Description

4-(Trimethylsilyl)-3-Butyn-1-Amine is a versatile organosilicon building block featuring both a terminal alkyne and a primary amine functional group, protected by a trimethylsilyl (TMS) moiety. This bifunctional nature makes it a critical intermediate for constructing complex molecular architectures in advanced organic synthesis and pharmaceutical research. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries who require high-purity, reliable precursors for click chemistry, peptide coupling, and the development of novel silicon-containing compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of new drug candidates via click chemistry (CuAAC) and amide bond formation.
• Agrochemical Synthesis: Used in the research and production of novel pesticides and herbicides, where the silicon group can influence bioavailability and stability.
• Material Science & Polymer Chemistry: Serves as a monomer or cross-linking agent for creating specialty polymers, dendrimers, and silicon-based hybrid materials with tailored properties.
• Bioconjugation & Probe Development: Enables the labeling of biomolecules (proteins, peptides, nucleic acids) with fluorescent or other reporter tags for diagnostic and research applications.
• Organic Synthesis Reagent: A valuable reagent for introducing protected alkyne and amine functionalities in multi-step synthetic routes, including the preparation of unnatural amino acids and complex natural product analogs.

Basic Information

Product Name	4-(Trimethylsilyl)-3-Butyn-1-Amine
CAS No.	183208-71-1
Molecular Formula	C7H15NSi
Molecular Weight	141.29 g/mol
Synonyms	3-Butyn-1-amine, 4-(trimethylsilyl)-; 4-(Trimethylsilyl)but-3-yn-1-amine; (4-Aminobut-1-yn-1-yl)trimethylsilane; N-(3-Butynyl)trimethylsilylamine; TMS-Protected Propargylamine; Trimethyl(3-butynyl)silaneamine; 4-Trimethylsilyl-3-butynylamine
EINECS	Contact for details

Quality Control

Our 4-(Trimethylsilyl)-3-Butyn-1-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.