Description

5-Bromo-1H-Pyrrolo[2,3-B]Pyridin-2(3H)-One is a high-value brominated heterocyclic building block, specifically a 7-azaindolin-2-one derivative. This compound is critical for medicinal chemistry research and development, serving as a versatile scaffold for constructing novel pharmacologically active molecules. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of kinase inhibitors and other targeted therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potent and selective kinase inhibitors, particularly for oncology targets.
• Medicinal Chemistry Scaffold: Used extensively in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR).
• Biochemical Probe Development: Employed in creating tool compounds for studying cellular signaling pathways and target validation.
• Organic Synthesis Building Block: Utilized in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for introducing complex molecular diversity.
• Agrochemical Research: Investigated as an intermediate for developing novel crop protection agents with specific modes of action.

Basic Information

Product Name	5-Bromo-1H-Pyrrolo[2,3-B]Pyridin-2(3H)-One
CAS No.	183208-34-6
Molecular Formula	C7H5BrN2O
Molecular Weight	213.03 g/mol
Synonyms	5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-2-one; 5-Bromo-7-azaindolin-2-one; 5-Bromo-1H-pyrrolo[2,3-b]pyridin-2-ol; 5-Bromo-2-hydroxy-1H-pyrrolo[2,3-b]pyridine; 5-Bromo-2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine; 5-Bromo-1,7-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one; 183208-34-6
EINECS	Contact for details

Quality Control

Our 5-Bromo-1H-Pyrrolo[2,3-B]Pyridin-2(3H)-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.