Description

1H-Pyrrolo[2,3-B]Pyridine, 1-[(1,1-Dimethylethyl)Dimethylsilyl]- is a high-purity, organosilicon-protected heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in providing a versatile and reactive scaffold for constructing complex molecular architectures, particularly in pharmaceutical research and development. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly those targeting kinase inhibition and other biological pathways.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging its heterocyclic core for bioactivity.
• Material Science: Acts as a building block for organic semiconductors, ligands for catalysts, and other functional organic materials.
• Academic & Contract Research: Employed in universities and CROs (Contract Research Organizations) for methodological studies and the discovery of new chemical entities.
• Peptidomimetics & Bioisosteres: The pyrrolopyridine core is valuable for designing peptide mimics and bioisosteric replacements in medicinal chemistry.
• Scale-up Process Development: Used in pilot plants and kilo labs to develop and optimize scalable synthetic routes for commercial production.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 1-[(1,1-Dimethylethyl)Dimethylsilyl]-
CAS No.	183001-71-0
Molecular Formula	C13H22N2Si
Molecular Weight	234.41 g/mol
Synonyms	1-(tert-Butyldimethylsilyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 1-[(1,1-dimethylethyl)dimethylsilyl]-; 1-TBDMS-1H-pyrrolo[2,3-b]pyridine; 1-(tert-Butyldimethylsilyl)-7-azaindole; 7-Azaindole, 1-(tert-butyldimethylsilyl)-; 1-TBDMS-7-azaindole; N-TBDMS-7-azaindole; tert-Butyldimethyl(7-azaindol-1-yl)silane
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine, 1-[(1,1-Dimethylethyl)Dimethylsilyl]- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is sensitive to fluoride and strong alkali; ensure it is stored separately from such materials. For long-term storage, consider keeping the container under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.