Description

Pyridine, 5-(Bromomethyl)-2-Chloro- (9Ci) is a high-value halogenated pyridine derivative, a crucial building block in advanced organic synthesis. Its bifunctional reactivity, featuring both bromomethyl and chloro substituents on the pyridine ring, makes it an essential intermediate for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry for creating drug candidates with pyridine-based cores.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the halogenated pyridine structure imparts specific biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands used in homogeneous catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic electronic materials, such as charge-transport layers or photoactive components.
• Cross-Coupling Reactions: The bromomethyl group is amenable to various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for carbon-carbon bond formation.
• Functionalization and Derivatization: The reactive halogen sites allow for sequential functionalization, enabling the creation of diverse chemical libraries for screening.

Basic Information

Product Name	Pyridine, 5-(Bromomethyl)-2-Chloro- (9Ci)
CAS No.	182924-36-3
Molecular Formula	C7H7BrClN
Molecular Weight	220.49 g/mol
Synonyms	2-Chloro-5-(bromomethyl)pyridine; 5-(Bromomethyl)-2-chloropyridine; 2-Chloro-5-bromomethylpyridine; (2-Chloro-5-pyridinyl)methyl bromide; 2-Chloropyridine-5-methyl bromide; 5-Bromomethyl-2-chloropyridine; 2-Chloro-5-(bromomethyl)pyridine (9CI); 182924-36-3 (CAS)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure batch-to-batch consistency and compliance with industry standards. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to confirm identity and purity. Certificates of Analysis (COA) detailing all test results are available upon request. We adhere to a quality management system to support our commitment to supplying reliable, high-purity intermediates for critical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.