Description

2-Hydroxy-6-Chloropyridine-4-Carboxamide is a versatile heterocyclic building block with significant synthetic utility. This compound is valued for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and advanced agrochemicals. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and kinase inhibitors.
• Agrochemical Synthesis: Serves as a key building block for developing new-generation herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for metal catalysis and coordination chemistry research.
• Material Science Research: Employed in the synthesis of functionalized polymers and organic electronic materials due to its modifiable pyridine core.
• Chemical Biology Probes: Acts as a scaffold for creating molecular probes to study enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects and scale-up activities.

Basic Information

Product Name	2-Hydroxy-6-Chloropyridine-4-Carboxamide
CAS No.	182483-97-2
Molecular Formula	C6H5ClN2O2
Molecular Weight	172.57 g/mol
Synonyms	6-Chloro-2-hydroxypyridine-4-carboxamide; 4-Carbamoyl-6-chloro-2-pyridinol; 6-Chloro-2-pyridone-4-carboxamide; 2-Pyridinol, 6-chloro-, 4-carboxamide; 6-Chloro-4-carbamoyl-2(1H)-pyridinone; 2-Hydroxy-6-chloroisonicotinamide; 6-Chloro-2-hydroxyisonicotinamide
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-6-Chloropyridine-4-Carboxamide is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.