Description

Fmoc-Cys(Acm)-Osu CAS NO 182410-75-9 is a high-purity, protected amino acid derivative widely used as a critical building block in solid-phase peptide synthesis (SPPS). Its value lies in the orthogonal protection strategy it provides, where the Fmoc group offers base-labile N-terminal protection and the Acm (acetamidomethyl) group provides side-chain protection for cysteine that is stable to the conditions of Fmoc deprotection, allowing for selective disulfide bond formation in complex peptides. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences industries developing therapeutic peptides, peptide hormones, and diagnostic reagents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental reagent for the controlled, sequential assembly of peptide chains using Fmoc chemistry protocols.
• Therapeutic Peptide Manufacturing: Used in the production of peptide-based pharmaceuticals, including hormones, antimicrobial peptides, and targeted therapeutics that require precise cysteine incorporation.
• Disulfide Bridge Formation: The Acm-protected cysteine side chain allows for the regioselective formation of intramolecular or intermolecular disulfide bonds, which are crucial for the biological activity and stability of many peptides.
• Peptide Library Construction: Employed in combinatorial chemistry for generating diverse peptide libraries for drug discovery and screening applications.
• Bioconjugation and Labeling: Serves as a precursor for introducing cysteine residues into peptides designed for site-specific conjugation with fluorophores, polymers, or other biomolecules.
• Research & Development: A key tool in academic and industrial R&D labs for studying protein folding, peptide structure-activity relationships (SAR), and developing novel bioactive compounds.

Basic Information

Product Name	Fmoc-Cys(Acm)-Osu
CAS No.	182410-75-9
Molecular Formula	C25H25N3O7S
Molecular Weight	511.55 g/mol
Synonyms	Fmoc-Cys(Acm)-OSu; N-(9-Fluorenylmethoxycarbonyl)-S-acetamidomethyl-L-cysteine N-Hydroxysuccinimide Ester; Fmoc-Cysteine(Acm)-OSu; Fmoc-S-acetamidomethyl-L-cysteine N-succinimidyl ester; Fmoc-L-Cys(Acm)-OSu; N-α-Fmoc-S-acetamidomethyl-L-cysteine N-hydroxysuccinimide ester; (2,5-Dioxopyrrolidin-1-yl) (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[(2-acetamidoethyl)sulfanyl]propanoate
EINECS	Contact for details

Quality Control

Our Fmoc-Cys(Acm)-Osu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment, NMR and IR for structural confirmation, and chiral analysis to verify enantiomeric purity. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. This material is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture uptake. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.