Description

n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-o-[3,4,6-Tri-o-Acetyl-2-(Acetylamino)-2-Deoxy-α-D-Glucopyranosyl]-L-Threonine Pentafluorophenyl Ester is a sophisticated, high-purity building block designed for advanced peptide and glycopeptide synthesis. This compound is critical for researchers and manufacturers requiring precise glycosylation and controlled coupling reactions in complex biomolecule assembly. It is primarily utilized in pharmaceutical R&D for the development of novel therapeutics, including vaccines, antibiotics, and targeted biologics.

Application

• Glycopeptide Synthesis: A key activated ester intermediate for the solid-phase and solution-phase synthesis of glycosylated peptides and proteins.
• Pharmaceutical Research: Used in the discovery and development of new antibiotic and anticancer agents that target bacterial cell walls or specific cellular receptors.
• Bioconjugation: Facilitates the site-specific attachment of carbohydrate motifs to peptide backbones or other carrier molecules for creating targeted drug conjugates.
• Vaccine Development: Employed in constructing antigenic glycopeptide fragments for synthetic vaccine candidates.
• Chemical Biology Tools: Serves as a precursor for probes and inhibitors used to study glycosylation processes and carbohydrate-protein interactions.
• Process Development: Used in scaling up the production of therapeutic glycopeptides under current Good Manufacturing Practice (cGMP) guidelines.

Basic Information

Item	Details
Product Name	n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-o-[3,4,6-Tri-o-Acetyl-2-(Acetylamino)-2-Deoxy-α-D-Glucopyranosyl]-L-Threonine Pentafluorophenyl Ester
CAS No.	182369-94-4
Molecular Formula	C41H39F5N2O13
Molecular Weight	862.75 g/mol
Synonyms	Fmoc-Thr(Ac3-α-D-GlcNAc)-OPfp; Fmoc-L-Threonine[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-α-D-glucopyranosyl] Pentafluorophenyl Ester; Fmoc-Thr[Ac3-α-D-GlcNAc]-OPfp Ester; Fmoc-Sugar Amino Acid Pentafluorophenyl Ester; Glycosylated Fmoc-Amino Acid Pentafluorophenyl Ester; N-α-Fmoc-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyranosyl)-L-threonine pentafluorophenyl ester; Acetylated GlcNAc-Threonine Building Block
EINECS	Contact for details

Quality Control

Our n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-o-[3,4,6-Tri-o-Acetyl-2-(Acetylamino)-2-Deoxy-α-D-Glucopyranosyl]-L-Threonine Pentafluorophenyl Ester is produced and tested to meet the exacting standards required for pharmaceutical research and development. Each batch undergoes rigorous analytical characterization, including HPLC for purity and NMR for structural confirmation, to ensure batch-to-batch consistency and reliability. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Specific Rotation	Contact for details
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.