Description

N3-Peg2-Tos CAS NO 182347-24-6 is a specialized bifunctional linker molecule featuring an azide (N3) group and a tosylate (Tos) leaving group, connected by a short polyethylene glycol (PEG) spacer. This compound is critical for facilitating controlled conjugation and bioconjugation reactions in advanced chemical synthesis. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and materials science sectors for applications such as click chemistry, polymer modification, and the development of targeted drug delivery systems.

Application

• Bioconjugation and Click Chemistry: The azide group enables efficient, selective copper-catalyzed or strain-promoted azide-alkyne cycloaddition (CuAAC/SPAAC) with alkynes for labeling biomolecules like proteins, antibodies, and oligonucleotides.
• Polymer and Material Functionalization: Used to introduce reactive handles or specific functionalities into polymers, hydrogels, and surfaces for creating advanced functional materials.
• Prodrug and Linker Synthesis: Serves as a key building block in the design of cleavable linkers for antibody-drug conjugates (ADCs) and other targeted therapeutic agents.
• Chemical Probe Development: Essential for synthesizing probes for bioimaging, diagnostics, and activity-based protein profiling (ABPP) in life science research.
• Crosslinking Agent: Acts as a heterobifunctional crosslinker to connect two different molecules or materials via orthogonal reactive groups.
• Surface Modification: Facilitates the covalent attachment of molecules to nanoparticles, chips, or other solid supports for sensor and assay development.

Basic Information

Product Name	N3-Peg2-Tos
CAS No.	182347-24-6
Molecular Formula	C16H23N3O6S
Molecular Weight	385.44 g/mol
Synonyms	2-[2-(2-Azidoethoxy)ethoxy]ethyl 4-methylbenzenesulfonate; Azido-PEG2-tosylate; N3-PEG2-OTs; 1-Azido-3,6-dioxaoct-8-yl 4-toluenesulfonate; 8-Azido-3,6-dioxaoctyl tosylate; PEG2 azide tosylate; Azido-EG2-OTs; Heterobifunctional PEG linker N3-PEG2-OTs
EINECS	Contact for details

Quality Control

Our N3-Peg2-Tos is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets high-grade specifications suitable for research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. For long-term storage under inert atmosphere, consider storing under argon or nitrogen. Keep container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.