Description

Arzoxifene Hcl CAS NO 182133-27-3 is a high-purity, nonsteroidal selective estrogen receptor modulator (SERM) compound. It is a critical pharmaceutical intermediate and research chemical used in the development of novel therapeutic agents. This compound is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers engaged in oncology and metabolic disease research.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of advanced SERM-based drug candidates for clinical research.
• Biomedical Research: Used as a reference standard and active compound in in vitro and in vivo studies investigating estrogen receptor biology and signaling pathways.
• Oncology R&D: Employed in preclinical research for breast cancer and other hormone-dependent cancers to study therapeutic mechanisms and efficacy.
• Metabolic Disorder Studies: Applied in research models for osteoporosis and other bone metabolism disorders to evaluate potential treatment effects.
• Chemical Synthesis: Acts as a precursor for the development of novel analogs and derivatives with modified pharmacological profiles.
• Analytical Standard: Provides a high-purity standard for method development and quality control in analytical laboratories (HPLC, LC-MS).

Basic Information

Product Name	Arzoxifene Hydrochloride
CAS No.	182133-27-3
Molecular Formula	C25H27NO4 • HCl
Molecular Weight	457.95 g/mol
Synonyms	Arzoxifene HCl; Arzoxifene Hydrochloride; LY353381 Hydrochloride; 6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl 4-[2-(1-piperidinyl)ethoxy]phenyl ketone Hydrochloride; (6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl)(4-(2-(piperidin-1-yl)ethoxy)phenyl)methanone Hydrochloride; Benzothiophene SERM LY353381 HCl; SERM III Hydrochloride
EINECS	Contact for details

Quality Control

Our Arzoxifene Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to ensure traceability and compliance with your research or manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.