Description

Arzoxifene is a selective estrogen receptor modulator (SERM) with a distinct pharmacological profile. This compound is of significant interest for advanced research and development within the pharmaceutical and life sciences sectors. It serves as a critical intermediate and reference standard for scientists working in oncology, endocrinology, and drug discovery.

Application

• Pharmaceutical Research & Development: Primary use as a reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel SERM therapies.
• Oncological Studies: Investigation of its effects on estrogen receptor-positive cancers, including breast cancer, due to its SERM activity.
• Biochemical Research: Used as a tool compound to study estrogen receptor signaling pathways and mechanisms of action in cellular and molecular biology.
• Academic & Institutional Research: Serves as a key material for universities and research institutes conducting studies in hormone-related diseases and drug mechanisms.
• Contract Manufacturing (CMO): Supplied as a high-purity building block for the synthesis of more complex molecules in custom manufacturing projects.
• Preclinical Development: Utilized in the formulation and testing stages of new drug candidates prior to clinical trials.

Basic Information

Product Name	Arzoxifene
CAS No.	182133-25-1
Molecular Formula	C25H27NO4S
Molecular Weight	437.55 g/mol
Synonyms	Arzoxifene; LY353381; (6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl)(4-(2-(1-piperidinyl)ethoxy)phenyl)methanone; Benzothiophene Methanone Derivative LY 353381; SERM LY353381; Arzoxifene Hydrochloride (salt form precursor)
EINECS	Contact for details

Quality Control

Our Arzoxifene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis to ensure it meets stringent specifications for research use. Certificates of Analysis (COA) detailing all test results are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.