Description

2-Mercapto-4-Methyl-6-Trifluoromethyl-Nicotinonitrile is a high-value, multi-functional heterocyclic building block featuring a reactive thiol group and a nitrile moiety. This compound is critical for advanced organic synthesis, particularly in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group for enhanced biological activity and metabolic stability.
• Ligand and Catalyst Development: The thiol and nitrile functionalities make it a valuable starting material for creating custom ligands for metal catalysis and organocatalysts.
• Material Science Research: Serves as a monomer or cross-linking agent in the research of advanced polymers and functional materials with specific electronic or surface properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and protein interactions.

Basic Information

Product Name	2-Mercapto-4-Methyl-6-Trifluoromethyl-Nicotinonitrile
CAS No.	182127-90-8
Molecular Formula	C8H5F3N2S
Molecular Weight	218.20 g/mol
Synonyms	6-(Trifluoromethyl)-4-methyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile; 4-Methyl-6-(trifluoromethyl)-2-mercaptonicotinonitrile; 2-Mercapto-4-methyl-6-(trifluoromethyl)nicotinonitrile; 2-Thioxo-1,2-dihydro-6-(trifluoromethyl)-4-methylnicotinonitrile; 2-Mercapto-4-methyl-6-trifluoromethyl-3-cyanopyridine
EINECS	Contact for details

Quality Control

Our 2-Mercapto-4-Methyl-6-Trifluoromethyl-Nicotinonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the stringent requirements of research and process chemistry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key specifications such as assay and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to handle and store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability, especially after opening the original packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.