Description

Carbamic Acid, [(1S,2S)-1-Ethynyl-2-Methylbutyl]-, 1,1-Dimethylethyl Ester (9Ci) is a specialized chiral building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of complex, biologically active molecules, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing novel molecular architectures with high stereochemical purity.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), especially in exploratory medicinal chemistry.
• Agrochemical Research: Used in the development of new, stereoselective pesticides and herbicides where specific spatial configuration is crucial for activity.
• Asymmetric Synthesis: Serves as a versatile precursor in catalytic asymmetric reactions to introduce complex, functionalized alkyl chains.
• Peptidomimetics & PROTACs: Employed in the construction of peptide analogs and Proteolysis Targeting Chimeras (PROTACs) due to its carbamate-protected amine and alkyne functionality.
• Ligand & Catalyst Development: Acts as a starting material for creating novel chiral ligands and organocatalysts for stereoselective transformations.
• Chemical Biology Probes: Utilized in synthesizing molecular probes for studying enzyme function and biological pathways via its reactive alkyne handle.

Basic Information

Product Name	Carbamic Acid, [(1S,2S)-1-Ethynyl-2-Methylbutyl]-, 1,1-Dimethylethyl Ester (9Ci)
CAS No.	181760-14-5
Molecular Formula	C13H21NO2
Molecular Weight	223.31 g/mol
Synonyms	(1S,2S)-1-Ethynyl-2-methylbutyl carbamic acid tert-butyl ester; tert-Butyl N-[(1S,2S)-1-ethynyl-2-methylbutyl]carbamate; (1S,2S)-1-Ethynyl-2-methylbutyl tert-butylcarbamate; BOC-Protected (1S,2S)-1-Ethynyl-2-methylbutylamine; (1S,2S)-1-Ethynyl-2-methylbutylamine N-BOC derivative; tert-Butyl ((1S,2S)-1-ethynyl-2-methylbutyl)carbamate; Carbamic acid, N-[(1S,2S)-1-ethynyl-2-methylbutyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our production of Carbamic Acid, [(1S,2S)-1-Ethynyl-2-Methylbutyl]-, 1,1-Dimethylethyl Ester (9Ci) adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture uptake. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.