Description

Proline, 1-Acetyl-5-Oxo-, Methyl Ester is a specialized proline derivative characterized by its acetyl and keto-ester functional groups. This compound serves as a valuable chiral building block and synthetic intermediate in advanced organic synthesis, enabling the construction of complex molecular architectures. It is primarily utilized by pharmaceutical research and fine chemical industries for developing novel active ingredients and other high-value chemical entities.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in peptide mimetics and protease inhibitors.
• Organic Synthesis Building Block: Used in asymmetric synthesis and multi-step reactions to introduce proline-based scaffolds with defined stereochemistry.
• Biochemical Research: Employed in the study of enzyme mechanisms and as a precursor for labeled compounds in metabolic pathway analysis.
• Agrochemical Development: Serves as an intermediate in the synthesis of advanced, biologically active compounds for crop protection.
• Material Science Research: Potential monomer or modifier in the development of specialized polymers with unique properties.

Basic Information

Product Name	Proline, 1-Acetyl-5-Oxo-, Methyl Ester
CAS No.	181312-04-9
Molecular Formula	C8H11NO4
Molecular Weight	185.18 g/mol
Synonyms	1-Acetyl-5-oxoproline methyl ester; Methyl 1-acetyl-5-oxoproline; Methyl 1-acetyl-5-oxo-L-prolinate; 5-Oxo-1-pyrrolidineacetic acid, 1-acetyl-, methyl ester; Acetyl-5-oxoproline methyl ester; Proline derivative CAS 181312-04-9; (S)-1-Acetyl-5-oxopyrrolidine-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Proline, 1-Acetyl-5-Oxo-, Methyl Ester is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for research and synthesis. A Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation. For long-term storage, consider using a desiccator or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.