Description

Methyl 1,4,5,6-Tetrahydro-2-Methyl-6-Oxopyridine-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), offering a versatile scaffold for medicinal chemistry research and development. It is primarily sought after by R&D laboratories, custom synthesis providers, and manufacturers in the pharmaceutical and agrochemical sectors.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, leveraging its heterocyclic structure.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and APIs under cGMP conditions.
• Chemical Reference Standard: Used as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	Methyl 1,4,5,6-Tetrahydro-2-Methyl-6-Oxopyridine-3-Carboxylate
CAS No.	181306-05-8
Molecular Formula	C8H11NO3
Molecular Weight	169.18 g/mol
Synonyms	Methyl 2-methyl-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 1,4,5,6-tetrahydro-2-methyl-6-oxo-, methyl ester; 1,4,5,6-Tetrahydro-2-methyl-6-oxo-3-pyridinecarboxylic acid methyl ester; Methyl 2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxylate; 6-Oxo-2-methyl-1,4,5,6-tetrahydropyridine-3-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 1,4,5,6-Tetrahydro-2-Methyl-6-Oxopyridine-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all specified parameters. We support development and commercial projects requiring material that meets ICH Q7 guidelines and other relevant pharmaceutical standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.