Description

1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylic Acid, 3-Amino-1-Methyl-, Ethyl Ester is a high-purity, heterocyclic organic building block of significant importance in advanced pharmaceutical research and development. This compound serves as a critical intermediate for synthesizing novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor programs. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of kinase inhibitors and other targeted therapeutics.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel drug candidates.
• Chemical Biology Probes: Serves as a scaffold for developing tool compounds to study biological pathways and target validation.
• Process Chemistry Development: Employed in route scouting and scale-up optimization for the commercial manufacturing of APIs.
• Custom Synthesis & Contract Manufacturing: A vital starting material for CDMOs (Contract Development and Manufacturing Organizations) offering bespoke chemical services.
• Academic Research: Utilized in university and institutional labs for pioneering research in heterocyclic and organic chemistry.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylic Acid, 3-Amino-1-Methyl-, Ethyl Ester
CAS No.	181283-92-1
Molecular Formula	C11H13N3O2
Molecular Weight	219.24 g/mol
Synonyms	3-Amino-1-methyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester; Ethyl 3-amino-1-methyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylate; 1-Methyl-3-amino-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester; 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 3-amino-1-methyl-, ethyl ester; 181283-92-1; 7-Azaindole-2-carboxylate derivative
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylic Acid, 3-Amino-1-Methyl-, Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow powder or crystalline solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.