Description

3-Bromo-4-Chloropyridine Hcl is a high-purity halogenated pyridine derivative, a crucial building block in advanced organic synthesis. Its value lies in providing a reactive scaffold for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for their R&D and production processes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the development of advanced pesticides, herbicides, and fungicides where the pyridine core is a critical structural component.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in metal-catalyzed cross-coupling reactions.
• Material Science Research: Employed in the synthesis of functionalized organic materials and liquid crystals.
• Chemical Biology Probes: Utilized to create tagged molecules for studying biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: A fundamental building block for custom synthesis projects requiring specific halogenated pyridine motifs.

Basic Information

Product Name	3-Bromo-4-Chloropyridine Hcl
CAS No.	181256-18-8
Molecular Formula	C5H4BrClN • HCl
Molecular Weight	243.36 g/mol (Free base: 192.45 g/mol)
Synonyms	3-Bromo-4-chloropyridine hydrochloride; 4-Chloro-3-bromopyridine hydrochloride; Pyridine, 3-bromo-4-chloro-, hydrochloride (1:1); 3-Bromo-4-chloropyridine HCl salt; 3-Br-4-Cl-Pyridine•HCl; 181256-18-8 (CAS); 3-Bromo-4-chloro-pyridinium chloride
EINECS	Contact for details

Quality Control

Our 3-Bromo-4-Chloropyridine Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.